4 ms·

Based on what you've said about amines - I suspect you don't eat potatoes or tomatoes, right? There was a recent discussion here: https://news.ycombinator.com/

Based on what you've said about amines - I suspect you don't eat potatoes or tomatoes, right? There was a recent discussion here: https://news.ycombinator.com/item?id=29131983 https://news.ycombinator.com/item?id=29131983 I seem to have a very mild version of the same thing, but I can have one of the 'dangerous' types of amine rich food every so often. Anyway, I commend your engineers approach and working out what is good for you.

FollowingTheDao 5y ago
Every so often is fine for me now as well but it is a crap shoot that sometime I regret. But now since I know what it is it does not bother me as much. If you are having trouble with amines you should think about trying high dose riboflavin. Riboflavin is the raw material for the enzyme (Monoamine Oxidase (MAOA and MAOB)) which metabolize all the amines. COMT does as well and magnesium and SAMe will help assist off that is your slow enzyme. Before I replenished my riboflavin I could not eat even lower amine foods. Riboflavin was my cure but then it started making me depressed which is what one would expect. Do you get migraines?
- eliasmacpherson 5y ago
  Curious that you should mention it. Yes I do get migraines, brought on by chocolate! I thought it was related to histamine. I used to think it was a tooth/dental hygeine issue but the migraine onset was way too fast for that. Is that a sign/marker of something? If so, where did you find that out? I eat salmon and steak semi regularly in order to avoid feeling terrible, b vitamin issues there I assume. Huge amounts of spinach for similar reasons.
  - FollowingTheDao 5y ago
    The link between high serotonin and some forms of migraines is well established. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ It either means your re making too much, cannot metabolize it, or you are too sensitive to serotonin. High does riboflavin has also been shown over and over to prevent some types of migraines. It will not cure one if you take it when you get it, but curing a functional deficiency looks like it would prevent them. It takes a while for the riboflavin to turn into FAD, the cofactor for MAOA. https://pubmed.ncbi.nlm.nih.gov/15257686/ https://pubmed.ncbi.nlm.nih.gov/15257686/ The Phenylethylamine in chocolate stimulates the release of serotonin. https://pubmed.ncbi.nlm.nih.gov/17105921/ https://pubmed.ncbi.nlm.nih.gov/17105921/ Speaking of histamine, most people do not know that mast cells, when they degranulate, not only release a ton of histamine, but also a lot of serotonin.
    - eliasmacpherson 5y ago
      Thanks for the tips! I had not read that about serotonin release. I'll add riboflavin to the list of things to play around with, along with levomefolic acid as recommended by the author of this comment here, who also mentioned serotonin: https://news.ycombinator.com/item?id=27990331 https://news.ycombinator.com/item?id=27990331 Might try this cyproheptadine/periactin too.
      - FollowingTheDao 5y ago
        I have never heard 5MTHF called levomefolic acid before. What is interesting abiut 5MTHF is that the enzyme MTHFR which creates it from folate needs riboflavin (FAD) as well. https://www.uniprot.org/uniprot/P42898 https://www.uniprot.org/uniprot/P42898 So riboflavin will solve both of these issues.
        Implicated 5y ago
        Would you be open to hearing out some ailments my partner has been dealing with that I feel you may have some insight on, or at least potentially shove me in the right starting direction? (prefer to do so in private communication, if so)
        FollowingTheDao 5y ago
        Sure. I sent you an email.

FollowingTheDao 5y ago

Every so often is fine for me now as well but it is a crap shoot that sometime I regret. But now since I know what it is it does not bother me as much. If you are having trouble with amines you should think about trying high dose riboflavin. Riboflavin is the raw material for the enzyme (Monoamine Oxidase (MAOA and MAOB)) which metabolize all the amines. COMT does as well and magnesium and SAMe will help assist off that is your slow enzyme. Before I replenished my riboflavin I could not eat even lower amine foods. Riboflavin was my cure but then it started making me depressed which is what one would expect. Do you get migraines?

eliasmacpherson 5y ago
Curious that you should mention it. Yes I do get migraines, brought on by chocolate! I thought it was related to histamine. I used to think it was a tooth/dental hygeine issue but the migraine onset was way too fast for that. Is that a sign/marker of something? If so, where did you find that out? I eat salmon and steak semi regularly in order to avoid feeling terrible, b vitamin issues there I assume. Huge amounts of spinach for similar reasons.
- FollowingTheDao 5y ago
  The link between high serotonin and some forms of migraines is well established. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ It either means your re making too much, cannot metabolize it, or you are too sensitive to serotonin. High does riboflavin has also been shown over and over to prevent some types of migraines. It will not cure one if you take it when you get it, but curing a functional deficiency looks like it would prevent them. It takes a while for the riboflavin to turn into FAD, the cofactor for MAOA. https://pubmed.ncbi.nlm.nih.gov/15257686/ https://pubmed.ncbi.nlm.nih.gov/15257686/ The Phenylethylamine in chocolate stimulates the release of serotonin. https://pubmed.ncbi.nlm.nih.gov/17105921/ https://pubmed.ncbi.nlm.nih.gov/17105921/ Speaking of histamine, most people do not know that mast cells, when they degranulate, not only release a ton of histamine, but also a lot of serotonin.
  - eliasmacpherson 5y ago
    Thanks for the tips! I had not read that about serotonin release. I'll add riboflavin to the list of things to play around with, along with levomefolic acid as recommended by the author of this comment here, who also mentioned serotonin: https://news.ycombinator.com/item?id=27990331 https://news.ycombinator.com/item?id=27990331 Might try this cyproheptadine/periactin too.
    - FollowingTheDao 5y ago
      I have never heard 5MTHF called levomefolic acid before. What is interesting abiut 5MTHF is that the enzyme MTHFR which creates it from folate needs riboflavin (FAD) as well. https://www.uniprot.org/uniprot/P42898 https://www.uniprot.org/uniprot/P42898 So riboflavin will solve both of these issues.
      - Implicated 5y ago
        Would you be open to hearing out some ailments my partner has been dealing with that I feel you may have some insight on, or at least potentially shove me in the right starting direction? (prefer to do so in private communication, if so)
        FollowingTheDao 5y ago
        Sure. I sent you an email.