Also, I think there are plenty of mutations that do negatively affect all four areas. For example: Down syndrome, Williams syndrome, Rubinstein-Taybi syndrome.

Also, I think there are plenty of mutations that do negatively affect all four areas. For example: Down syndrome, Williams syndrome, Rubinstein-Taybi syndrome. (The "beauty" is subjective, of course, but I expect people's sense of "beauty" to be optimized towards "avoiding potential mates with genetic defects".) I knew about the first two; I learned about the third by clicking on a few entries in https://en.wikipedia.org/wiki/Category:Syndromes_with_craniofacial_abnormalities https://en.wikipedia.org/wiki/Category:Syndromes_with_cranio... . I expect there are plenty more mutations that have a mild negative effect in all areas, but are sufficiently mild that they haven't been identified as "disorders".