3 ms·
The whole NBOMe/NBOH series are notorious for that. Some people have incredible visuals and a gentle time, others go psychotic or randomly die. There are other
by sterlind 5y ago
The whole NBOMe/NBOH series are notorious for that. Some people have incredible visuals and a gentle time, others go psychotic or randomly die.
There are other dangerous phenethylamines, of course. Bromo-DragonFLY caused vasoconstriction which resulted in amputations or strokes in overdose, many others including the 2C-Ts are MAOIs. And even LSD has catastrophic effects when taken with lithium. But there's something about the NBOMes, maybe off-target effects, that makes them terrifying.
...which is a shame because having a new backbone to play with would be super fun. we have phenethylamines and tryptamines and ergolides, but there's only so much you can tweak them. hopefully - eventually - Shulgin's style of gonzo pharmacology will be allowed again, and someone will discover more magic keys.
- sterlind 5y agoCan't edit my post anymore, but researched and (some of?) the NBOMe toxicity appears to be from rhabdomyolysis (your muscles break down, releasing proteins that cause your kidneys to fail.) Source: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5552826/ https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5552826/ They reproduced it in zebrafish, apparently. They suggest using 25B as an actual research chemical to study serotonin-induced rhabdo in lab animals shudder.