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> I never understood why people would want to take drugs to see the shit and live the suffering I have all my life but that's where we are... Well, it sounds l

> I never understood why people would want to take drugs to see the shit and live the suffering I have all my life but that's where we are... Well, it sounds like you're having a bad time in your life with all of those things, and as a drug user myself, that's not the goal with my usage, and neither the effects it has on me.

FollowingTheDao 5y ago
Yes, I can see how a bit of this would help someone not as sensitive to trace amines as I am. I am in no way ADHD and when I was fist seeing a doc for my mental illness they thought I was an prescribe me methamphetamines which threw me into a horrific manic state. It seems like the whole world need to get "up" and I feel like I am the only one trying to get "down". =/ Anyway, vodka is the greatest drug for me, as is klonopin. Klonopin can take me right out of my schizoaffective states. But I eat low protein, only seafood and take a bunch of zinc which all seems to help. I wonder, if people do well on these trace amines, what is the blockage in the genetics? Not enough B6 to make the trace amines I wonder? Too much zinc?
- netizen-936824 5y ago
  Sounds like you have some malfunctioning enzymes somewhere. Genetic testing (through a reputable medical provider, not 23andme) may provide some interesting results
  - FollowingTheDao 5y ago
    Yes, I have two runs from 23 and me one of the version four chip in one of the version five chip. I’m also waiting for my full genome that should be coming in about 5 to 6 weeks. I’m well aware of my genetics and how they helped cause my mood disorder and my various sensitivities. I spent the last 12 years teaching myself genetics and nutritional genetics as well as neuropsychology so I could figure out what was happening to my family. Turns out we have Sami heritage we never knew we had which I think is part of the disconnect.
    - eliasmacpherson 5y ago
      Based on what you've said about amines - I suspect you don't eat potatoes or tomatoes, right? There was a recent discussion here: https://news.ycombinator.com/item?id=29131983 https://news.ycombinator.com/item?id=29131983 I seem to have a very mild version of the same thing, but I can have one of the 'dangerous' types of amine rich food every so often. Anyway, I commend your engineers approach and working out what is good for you.
      - FollowingTheDao 5y ago
        Every so often is fine for me now as well but it is a crap shoot that sometime I regret. But now since I know what it is it does not bother me as much. If you are having trouble with amines you should think about trying high dose riboflavin. Riboflavin is the raw material for the enzyme (Monoamine Oxidase (MAOA and MAOB)) which metabolize all the amines. COMT does as well and magnesium and SAMe will help assist off that is your slow enzyme. Before I replenished my riboflavin I could not eat even lower amine foods. Riboflavin was my cure but then it started making me depressed which is what one would expect. Do you get migraines?
        eliasmacpherson 5y ago
        Curious that you should mention it. Yes I do get migraines, brought on by chocolate! I thought it was related to histamine. I used to think it was a tooth/dental hygeine issue but the migraine onset was way too fast for that. Is that a sign/marker of something? If so, where did you find that out? I eat salmon and steak semi regularly in order to avoid feeling terrible, b vitamin issues there I assume. Huge amounts of spinach for similar reasons.
        FollowingTheDao 5y ago
        The link between high serotonin and some forms of migraines is well established. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ It either means your re making too much, cannot metabolize it, or you are too sensitive to serotonin. High does riboflavin has also been shown over and over to prevent some types of migraines. It will not cure one if you take it when you get it, but curing a functional deficiency looks like it would prevent them. It takes a while for the riboflavin to turn into FAD, the cofactor for MAOA. https://pubmed.ncbi.nlm.nih.gov/15257686/ https://pubmed.ncbi.nlm.nih.gov/15257686/ The Phenylethylamine in chocolate stimulates the release of serotonin. https://pubmed.ncbi.nlm.nih.gov/17105921/ https://pubmed.ncbi.nlm.nih.gov/17105921/ Speaking of histamine, most people do not know that mast cells, when they degranulate, not only release a ton of histamine, but also a lot of serotonin.
- capableweb 5y ago
  > It seems like the whole world need to get "up" and I feel like I am the only one trying to get "down". =/ Quoting the novel that was mentioned elsewhere in this thread (and the title of the article seems to be named after too): > We had two bags of grass, seventy-five pellets of mescaline, five sheets of high powered blotter acid, a salt shaker half full of cocaine, and a whole galaxy of multi-colored uppers, downers, screamers, laughers... and also a quart of tequila, a quart of rum, a case of Budweiser, a pint of raw ether and two dozen amyls Not all drugs are for "getting up" or even "getting down", there is a whole spectrum of effects you can feel by different drugs (or combination of drugs even).
  - netizen-936824 5y ago
    There are such a wide variety of effects when it comes to psychoactive substances, that's one of the most fascinating things to me about drugs. There's far more to the toolbox than "get up and go fast"

FollowingTheDao 5y ago

Yes, I can see how a bit of this would help someone not as sensitive to trace amines as I am. I am in no way ADHD and when I was fist seeing a doc for my mental illness they thought I was an prescribe me methamphetamines which threw me into a horrific manic state. It seems like the whole world need to get "up" and I feel like I am the only one trying to get "down". =/ Anyway, vodka is the greatest drug for me, as is klonopin. Klonopin can take me right out of my schizoaffective states. But I eat low protein, only seafood and take a bunch of zinc which all seems to help. I wonder, if people do well on these trace amines, what is the blockage in the genetics? Not enough B6 to make the trace amines I wonder? Too much zinc?

netizen-936824 5y ago
Sounds like you have some malfunctioning enzymes somewhere. Genetic testing (through a reputable medical provider, not 23andme) may provide some interesting results
- FollowingTheDao 5y ago
  Yes, I have two runs from 23 and me one of the version four chip in one of the version five chip. I’m also waiting for my full genome that should be coming in about 5 to 6 weeks. I’m well aware of my genetics and how they helped cause my mood disorder and my various sensitivities. I spent the last 12 years teaching myself genetics and nutritional genetics as well as neuropsychology so I could figure out what was happening to my family. Turns out we have Sami heritage we never knew we had which I think is part of the disconnect.
  - eliasmacpherson 5y ago
    Based on what you've said about amines - I suspect you don't eat potatoes or tomatoes, right? There was a recent discussion here: https://news.ycombinator.com/item?id=29131983 https://news.ycombinator.com/item?id=29131983 I seem to have a very mild version of the same thing, but I can have one of the 'dangerous' types of amine rich food every so often. Anyway, I commend your engineers approach and working out what is good for you.
    - FollowingTheDao 5y ago
      Every so often is fine for me now as well but it is a crap shoot that sometime I regret. But now since I know what it is it does not bother me as much. If you are having trouble with amines you should think about trying high dose riboflavin. Riboflavin is the raw material for the enzyme (Monoamine Oxidase (MAOA and MAOB)) which metabolize all the amines. COMT does as well and magnesium and SAMe will help assist off that is your slow enzyme. Before I replenished my riboflavin I could not eat even lower amine foods. Riboflavin was my cure but then it started making me depressed which is what one would expect. Do you get migraines?
      - eliasmacpherson 5y ago
        Curious that you should mention it. Yes I do get migraines, brought on by chocolate! I thought it was related to histamine. I used to think it was a tooth/dental hygeine issue but the migraine onset was way too fast for that. Is that a sign/marker of something? If so, where did you find that out? I eat salmon and steak semi regularly in order to avoid feeling terrible, b vitamin issues there I assume. Huge amounts of spinach for similar reasons.
        FollowingTheDao 5y ago
        The link between high serotonin and some forms of migraines is well established. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/ It either means your re making too much, cannot metabolize it, or you are too sensitive to serotonin. High does riboflavin has also been shown over and over to prevent some types of migraines. It will not cure one if you take it when you get it, but curing a functional deficiency looks like it would prevent them. It takes a while for the riboflavin to turn into FAD, the cofactor for MAOA. https://pubmed.ncbi.nlm.nih.gov/15257686/ https://pubmed.ncbi.nlm.nih.gov/15257686/ The Phenylethylamine in chocolate stimulates the release of serotonin. https://pubmed.ncbi.nlm.nih.gov/17105921/ https://pubmed.ncbi.nlm.nih.gov/17105921/ Speaking of histamine, most people do not know that mast cells, when they degranulate, not only release a ton of histamine, but also a lot of serotonin.
capableweb 5y ago
> It seems like the whole world need to get "up" and I feel like I am the only one trying to get "down". =/ Quoting the novel that was mentioned elsewhere in this thread (and the title of the article seems to be named after too): > We had two bags of grass, seventy-five pellets of mescaline, five sheets of high powered blotter acid, a salt shaker half full of cocaine, and a whole galaxy of multi-colored uppers, downers, screamers, laughers... and also a quart of tequila, a quart of rum, a case of Budweiser, a pint of raw ether and two dozen amyls Not all drugs are for "getting up" or even "getting down", there is a whole spectrum of effects you can feel by different drugs (or combination of drugs even).
- netizen-936824 5y ago
  There are such a wide variety of effects when it comes to psychoactive substances, that's one of the most fascinating things to me about drugs. There's far more to the toolbox than "get up and go fast"