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Ask HN: How to get into genetics/biology being over 30?
Hi HN!
I have been a long time lurker but got to a point now where I am stuck on how
to look for an answer and thought that this crowd might have some good
insight.
There was a question about how to raise funds for rare disease research
(https://news.ycombinator.com/item?id=30250496) posted yesterday that
felt like the last drop for me to try to pursue learning about genetics.
If one wants to learn about how the genetic code works, how proteins work, and
be able to investigate their functions what kind of undergrad program does one
need to apply to? I still have trouble explaining what exactly I am trying to
do, but let me try:
For various times in my life I've thought I should study genetics and try to
learn about how life works in its essence. For the past few months, I have
been stumbling upon various posts and websites that talk about new discoveries
on understanding of human genome, therapies being developed and so on. Almost
as if getting a sign that I should dive into learning it as it is something
that I feel I am interested in. Knowing how to code definitely seems to be
something that helps, but I don't want to work on simply getting genetic data
I don't understand and write software that apply transformations or generate
visualizations of this kind of data and make it available for scientists to do
what I deem to be the most interesting part of the work. I want to be able to
understand what the data means and be able to review and reflect about it and
give input to advance the understanding in the field.
So, if one wants to get in this field to be able to do research on how genes
relate to diseases and have a deeper understanding of protein formation and
inner workings as well as have access to equipment that would allow performing
this kind of research, what should one study? Is going back to college and
taking an undergrad course the best way? Or is there a way of learning this
kind of stuff at home (and if so, how does one do that)? I'd assume that it
might not be possible to go too far by studying at home just because without
access to equipment it might be very hard to make progress in this area.
I don't know if it matters, but I am in my mid 30s and my work is completely
unrelated. I work in security and programming, and have not had any kind of
exposure to this kind of biology other than what you learn at highschool (and
that was about 20 years ago). I am at a point where I feel my interest in the
field seems to be diminishing and I might be burnt out. For some years now I
have been trying to figure out what would be a different career path I could
try, but always ended up at a point where I felt none of them had any meaning
in the end. When I think about learning about this topic, I get this warm
feeling I haven't had in a while and don't have that dreaded feeling that my
work won't matter, because I genuinely think it can be important.
I wouldn't be doing this for the money (I honestly don't even know how much
money one makes in this line of work) but for the chance to learn, satisfy my
curiosity and with luck help advance our understanding of how living things
work. And hopefully being able to do this kind of work would allow me to offer
to help in situations such as the post mentioned above.
Any help or advice on how to proceed on this, or how to become a bit less
ignorant in order to be able to understand what exactly it is I am trying to
achieve would be very appreciated. Anyone working in the field that could
share their experience in it and how they got into it, would also be very
appreciated.
Thanks!
PS: Sorry if the line of thought is all over the place there, I was trying to
convey what I want to do and the way I am feeling about it while not missing
any information I think would be important.
PPS: The throwaway account is due to me mentioning burn out and not wanting to
have such information traced back to me.
- ArtWomb 5y agoWe're witnessing the bio century. CAR-T gene therapies have been demonstrated to "cure" cancer. And the coming Bio Cloud will liberate genomic experimentation for the masses. I found Eric Lander's intro course to be great. But it's a few years old now, and was wondering if there wasn't something more contemporary, with the latest state of the art techniques such as AlphaFold. Best of Luck ;) https://www.edx.org/course/introduction-to-biology-the-secret-of-life-3 https://www.edx.org/course/introduction-to-biology-the-secre...
- study_genetics 5y agoThis seems like a pretty good course and seems to match perfectly what I was looking for. Thank you very much for the pointer! As for it being a bit outdated, it should still be fine as it will at least give me a better understanding of things and help me being able to figure out other materials to study.
- JPLeRouzic 5y agoHi, I can relate to your feelings. I am 65, when I retired as a telecom R&D engineer I wanted to learn biology so I took a lot of Coursera courses and a few Edx. I did a specialization in system biology. System biology is especially interesting for engineers as it tends to use the same point of view as do engineers. Then I went to my local university to have master courses in bioinformatics. Then it happened that a guy in my step family got ALS (Lou's Gehrig disease). It was the second person to have it so I started to focus on familial ALS for obvious reasons. I have a blog with ~500 posts on neurodegenerative diseases and in 2019 I wrote a book on the state of ALS research that I keep updated every 6 months.
- study_genetics 5y agoIf you don't mind me asking, how long ago did you take those courses? Would you suggest me to take any of them? How do you go about doing such specialization? Just found a college that had the course and signed up to it? Was that in the US? Did you end up getting a job at the university to be able to conduct research? Or are you allowed to just visit and use their facilities for that? I will check your blog out and try to learn some from it. Thanks!