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> The data presented here are very likely not bias in the way your describing as it because of the contrast to both controls that would capture "it's always bee
by nwiswell 5y ago
> The data presented here are very likely not bias in the way your describing as it because of the contrast to both controls that would capture "it's always been that way" effect.
That's not really what I said -- I'm not actually taking a stance on the conclusions of this paper. COVID has obviously been infecting massive numbers of people in the last couple of years, and if it is responsible for long-term cardiovascular sequelae as the paper concludes, of course it would be a more acute contributor over that period as compared to other historical causes simply by virtue of its pervasiveness.
Rather what I said is that the disease itself may not be causing "havoc" in the body at rates significantly different than other endemic viruses ("havoc" writ large: not only confined to cardiovascular sequelae, but among any long-term systemic harms). The bias that I am proposing is that we are _noticing_ these sequelae because A) so many people are getting sick at the same time, and B) because we are paying this much attention for the first time ever.
- dv_dt 5y agoOther endemic viruses that don’t show up in the historical control group? What definition of endemic are you thinking of?
- nwiswell 5y agoLike I just emphasized, they may not show up as statistically significant because A) they are not pandemic, so the effect is of course much smaller B) their impact is not necessarily primarily cardiovascular Here's a non-exhaustive list of viruses with potentially overlooked sequelae. Shingles (herpes zoster) Rubella Rotavirus RSV Norovirus HPV Hepatitis Influenza This is totally orthogonal to any possible defects in this study, which again I am not taking any stance on. It's merely a question of whether this study is anomalous for having been conducted in the first place. If we assume that the study is flawless, that means that COVID has long term health impacts -- fine -- but do we actually know if that's unusual for a virus?