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Or that Omicron is mild enough that it would not have caused the disease to unboosted or completely unvaccinated subjects... had they included those groups in t
by ComradePhil 5y ago
Or that Omicron is mild enough that it would not have caused the disease to unboosted or completely unvaccinated subjects... had they included those groups in the study.
From the original paper:
> since we sought to compare two different mRNA boosts, we did not have an unboosted group to determine whether the boost enhanced protection.
How are they able to get away with deliberately bad study designs?
- 22c 5y agoI think it's enough for them to say to those who have already been vaccinated with mRNA-1273 that there's essentially a "vendor lock-in" effect going on and that using an Omicron (or whatever variant comes next) specific booster won't provide any more benefit (for better or worse) than simply getting another dose of the same vaccine they already had. I would be interested to know what would happen in the case where subjects have natural immunity then get mRNA-1273 then later get mRNA-1273.529. I would hypothesize that there would be a measurably different immune response to both the initial vaccine doses as well as the booster.