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The data suggests that this is a pointless waste of money “Despite the Herculean effort and enormous expense, only a few drugs for the treatment of cancer were
by kumarski 5y ago
The data suggests that this is a pointless waste of money
“Despite the Herculean effort and enormous expense, only a few drugs for the treatment of cancer were found through NCI’s centrally directed, targeted program. Over a twenty-year period of screening more than 144,000 plant extracts, representing about 15,000 species, not a single plant-based anticancer drug reached approved status. This failure stands in stark contrast to the discovery in the late 1950s of a major group of plant-derived cancer drugs, the Vinca Alcaloids -a discovery that came about by chance, not through directed research.” — Happy Accidents: Serendipity in Modern Medical Breakthroughs.
CRISPR-9 was discovered by accident while trying to understand how bacteria fight the flu. (CRISPR-9 is the acronym for gene editing brouhaha).
Penicillin was discovered via Alexander Fleming’s random mold observation.
Roentgen discovered X-ray tech by accident when he shot electric current through a special gass in a glass tube. Roentgen found out that he’d made a ray that passed through light elements, but interacted with heavy ones; the X-ray.
Vaccines were accidental too. (Edward Jenner — cowpox)
Directed effort seems to be a not-good bet in biotech.
Lesson: Let scientists advanced things in accordance with the invisible hand of scientific discovery and observation as opposed to subsidizing bridges to nowhere. Think more Ioannidis than Kurzweil.*
- TedDoesntTalk 5y ago> scientific discovery and observation as opposed to subsidizing bridges to nowhere But there are plenty of examples of research with directed effort leading to cures and treatments. You just choose not include any.
- jlcoff 5y agoSuch as ?
- zacharycohn 5y agoThis is just selection bias. I could produce a list - by memory - 10x longer of drugs and therapies that were produced intentionally.
- kumarski 5y agoI'm all ears, please produce examples of this that have occurred in the last 15-25 years outside of vaccines.