One good reason why the amyloid hypothesis persists in attracting support is that it is currently the only way to account for how the mutations in APP and prese

One good reason why the amyloid hypothesis persists in attracting support is that it is currently the only way to account for how the mutations in APP and presenilin cooperate to cause early onset familial Alzheimer's disease. In particular, out of the 695 amino acids that constitute the APP protein, all the mutations that cause disease are located within the 42 amino acids that comprise the amyloid peptide, or just next to it.