4 ms·
>Normally, when you have so many mutations all over, you expect that you will also have compromised the ability to bind the receptor I guess there have been th
by iqanq 5y ago
>Normally, when you have so many mutations all over, you expect that you will also have compromised the ability to bind the receptor
I guess there have been thousands of mutations with such compromised ability to bind the receptor that weren't viable enough to win and fizzled out?
- flobosg 5y agoYes, that’s right. Other possible effect of mutations in the spike protein can be, for example, disruption of the conformational change needed for ACE2 binding (the ‘down to up flip’ mentioned in the article). In fact, such a mutation is present in the spike protein expressed by mRNA vaccines.