although too late to help your father, anyone facing acquired resistance to PARP inhibitors should look into novobiocin [0]. novobiocin is an antibiotic develo

although too late to help your father, anyone facing acquired resistance to PARP inhibitors should look into novobiocin [0]. novobiocin is an antibiotic developed decades ago but recently "rediscovered" as offering anti-carcinogenic against some cancers which resist PARP inhibitors. in short, it targets an enzyme (polymerase theta) critical to these cancers. thanks for sharing this story. i'm so sorry for your loss, but it is amazing how such persistence and critical thinking offered your father and family another treasured year of life. he must have been unbelievably proud. [0] https://www.dana-farber.org/newsroom/news-releases/2021/antibiotic-novobiocin-found-to-kill-tumor-cells-with-dna-repair-glitch/ https://www.dana-farber.org/newsroom/news-releases/2021/anti...