2 ms·
every time I see a headline like this I always ask - which cancers - for whom - what's the trial size - what's the success rate - what's the cost the arti
by trynewideas 5y ago
every time I see a headline like this I always ask
- which cancers
- for whom
- what's the trial size
- what's the success rate
- what's the cost
the article answers some, to some degree:
- for "leukaemias, lymphomas and myelomas"
- not many; "relatively few US centres are capable of delivering it", "For people with lymphoma, the figure is around 1 in 5" people who could benefit are receiving it [1]
- "tens of thousands"
- "only about 25-35% of CAR-T cell recipients with chronic lymphocytic leukaemia experienced a complete remission"
- as of 2021 per Prime Therapeutics, "Although the wholesale acquisition cost of chimeric antigen receptor (CAR) T-cell therapies to treat B-cell lymphoma is $373,000, a new study by Prime Therapeutics of real-world data found that the total cost averages more than $700,000 and can exceed $1 million in some cases." [2]
[1] https://www.nature.com/articles/d41586-020-02675-w https://www.nature.com/articles/d41586-020-02675-w
[2] https://www.pharmacytimes.com/view/study-finds-total-cost-of-care-for-car-t-post-treatment-events-can-exceed-1-million https://www.pharmacytimes.com/view/study-finds-total-cost-of...
- mft_ 5y ago> - "only about 25-35% of CAR-T cell recipients with chronic lymphocytic leukaemia experienced a complete remission" Not sure why you picked CLL, which is but one of several diseases that CAR-Ts have been tested against, and which is so far unapproved. Response rates do vary, but are higher than you quote in B-ALL and DLBCL (the diseases that CAR-Ts were first approved for) 83% in B-ALL: https://www.nature.com/articles/nrd.2017.196 https://www.nature.com/articles/nrd.2017.196 82% in ref DLBCL: https://www.nejm.org/doi/full/10.1056/nejmoa1707447 https://www.nejm.org/doi/full/10.1056/nejmoa1707447 64% in DLBCL, 71% in FL: https://www.nejm.org/doi/full/10.1056/NEJMoa1708566 https://www.nejm.org/doi/full/10.1056/NEJMoa1708566