3 ms·
Also many people fail to seroconvert after natural infection: https://wwwnc.cdc.gov/eid/article/27/9/21-1042-f2 https://wwwnc.cdc.gov/eid/article/27/9/21-1042-
by lamontcg 5y ago
Also many people fail to seroconvert after natural infection:
https://wwwnc.cdc.gov/eid/article/27/9/21-1042-f2 https://wwwnc.cdc.gov/eid/article/27/9/21-1042-f2
And the virus contains immune evasion genes like ORF8 which evade humoral immunity responses by downregulating MHC-I:
https://www.pnas.org/content/118/23/e2024202118 https://www.pnas.org/content/118/23/e2024202118
Nobody in their right mind would produce a vaccine with ORF8 in it since it defeats the whole purpose of stimulating T-cell and B-cell recognition.
There's good reasons why natural immunity has been downplayed.
- dham 5y agoI'm sorry. Can you clarify what you are saying?