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mRNA vaccines don't use regular mRNA though, they use nucleoside analogues to avoid triggering an innate immune response to the mRNA itself. is it really that e
by sterlind 5y ago
mRNA vaccines don't use regular mRNA though, they use nucleoside analogues to avoid triggering an innate immune response to the mRNA itself. is it really that easy to homebrew that? plus encapsulating it into lipid nanoparticles etc. sounds like it'd be a major project..
- ImaCake 5y agoThe lipid vesicles part is pretty simple I think. You don’t need it to last a long time, just long enough to snort it up your nose. I am not sure about the XNAs. You might be able to get around it with increasing the dose (trivial if you are producing your own RNA) or it might be possible to use XNAs in a standard synthesis protocol. It would depend on the RNA Pol I think.