Truvada can be a bit hard on the kidneys. Before starting it you generally have to have some blood work done to check to see if you're likely to have issues, a

Truvada can be a bit hard on the kidneys. Before starting it you generally have to have some blood work done to check to see if you're likely to have issues, and at least for a period after starting it they usually want to do blood tests regularly to ensure the kidneys are functioning properly. So it's certainly not something that everyone can get. Descovy appears to be better, but I think it's not approved everywhere yet.