3 ms·
> "these are not the antibodies most humans develop in response to HIV." In many cases. One case, for example was identified from a prostitute in sub-saharan
by dnautics 5y ago
> "these are not the antibodies most humans develop in response to HIV."
In many cases. One case, for example was identified from a prostitute in sub-saharan africa who managed to be completely HIV-free. It turned out she had a mutation in her antibodies that caused the antibodies to latch onto things with four sites instead of just 2 (think X shaped instead of V shaped).
- andrewflnr 5y agoThat sounds fascinating. Got any links or search terms?
- dnautics 5y agohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136306/
- andrewflnr 5y agoAwesome.
- mlyle 5y agoThat's why I said "most humans". bnAbs are generally antibodies that are detected in (few) humans. In addition to the people with seeming immunity through missing receptors or unusual antibody morphology, there's also about 1 in 200 infected that are "elite controllers" that do not develop high viral loads or severe symptoms when infected by HIV-- generally in large part to their bodies making multiple bnAbs.
- dnautics 5y agoI wasn't contradicting you, I was adding more specifics.