3 ms·
No one in this thread knows anything about vaccines or infectious disease. Each organism is different and requires a detailed understanding to see what the pote
by tehjoker 5y ago
No one in this thread knows anything about vaccines or infectious disease. Each organism is different and requires a detailed understanding to see what the potential for the vaccine is. You can't just take COVID-19's performance and project that onto another disease. mRNA allows the targeting of specific proteins. The efficacy of the T-cell and B-cell responses are going to be highly dependent on that protein's structure, its importance and level of conservation in the pathogen, and other factors.
COVID-19 seems to require a persistently high level of neutralizing anti-bodies and the T-cell response seems to be less important (and also plays a role in auto-immunity). On the plus side, the wild-type vaccine has continued to be fairly effective against even highly mutated Omicron which is surprisingly good even if strategically, it is suboptimal that the virus has continued to mutate and evade the vaccine to ever greater degrees.