2 ms·
> Can’t you grow the peptide of interest and package it in a traditional vaccine? Traditional way to do this is recombinant approaches (mentioned). These are
by mlyle 5y ago
> Can’t you grow the peptide of interest and package it in a traditional vaccine?
Traditional way to do this is recombinant approaches (mentioned). These are also in progress. mRNA is much quicker to iterate, though. They tried a few candidate sequences in sHIV to guide their human vaccine development.
mRNA vaccines are kind of neat in the way that they create a few day long pulse of new virus-like particles showing up, to ensure the immune system gets really annoyed.
- throwaway2037 5y agoWhen you wrote <<sHIV>>, did you mean <<Simian immunodeficiency virus (SIV)>>? Ref: https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus
- mlyle 5y agoNo, I meant sHIV or SHIV, which are a family of human-created viruses with SIV structure and HIV sequences within. https://journals.asm.org/doi/10.1128/JVI.00372-19 https://journals.asm.org/doi/10.1128/JVI.00372-19