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Research also suggests that biofilm can be broken up by reducing inflammation generally in the body. So we have some options here for combatting antibiotic resi
by DoreenMichele 5y ago
Research also suggests that biofilm can be broken up by reducing inflammation generally in the body. So we have some options here for combatting antibiotic resistant infections. We just need to start focusing more on those approaches and less on finding novel or stronger antibiotics as our only answer.
Infections aren't stupid. They adapt. If you only have one tool, well, that's relatively easy to adapt to. We need to focus more on these adjunct therapies for enhancing the effectiveness of existing antibiotics.
- chasil 5y agoThe nice thing about phages is that they also adapt. 'Part of the treatment’s success is due to the “training of the phages,” says Pirnay. This involves directing the evolution of these viruses by growing one generation after the other alongside the bacteria that is infecting the patient. In each generation, the virus that kills the most bacteria is selected and moves to the next round. The result is an elite force of phages specially adapted to fight a specific pathogen... '“Phages are able to stop the bacteria from being resistant to antibiotics,” she says. “The bacteriophages attack the same molecular targets that bacterias use to avoid the effect of antibiotics. If you administer phages first, then antibiotics, you block their resistance and the infection subsides.”'
- ampdepolymerase 5y agoFwiw, rarely can lab designed viruses i.e. made through splicing have features that are more "optimal" (or efficient) than those that are evolved. Directed evolution is truly marvelous when done properly (it won a Nobel!).