3 ms·
The article discusses "training" phases, where the stock phage is applied to a sample of the specific pathogen, and only the most successful daughter phages are
by chasil 5y ago
The article discusses "training" phases, where the stock phage is applied to a sample of the specific pathogen, and only the most successful daughter phages are retained, over several repetitions.
This process of encouraging adaptation appears to greatly increase successful outcomes.
- sudosysgen 5y agoThat makes sense for resistant infections, but for general infections a pre-made stock should work, no?
- chasil 5y agoFor something that is already resistant to antibiotics, the training phase seems prudent. Exploiting evolution as part of the treatment leads to greater success. The emergence of phage-resistant pathogens should not be encouraged, as we have encouraged antibiotic resistance. I think it's a change in mindset, as well as a change in procedure.