> An alternative is to look at interventions that extend the lifespan of other animals. Some, such as calorie restriction, do seem to reduce epigenetic age in m

> An alternative is to look at interventions that extend the lifespan of other animals. Some, such as calorie restriction, do seem to reduce epigenetic age in mice. Nevertheless, Kaeberlein wants to see all such manipulations systematically investigated — and the proposition that clock scores can predict lifespans at the individual level tested. > He stresses the importance of reporting negative results, and determining whether all treatments that extend lifespan or improve late-life functionality decrease epigenetic age — as well as whether all interventions that decrease clock scores increase longevity. This is it, test the theory properly in mice. Forget doing poorly designed human trials until then.