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First and foremost I would suggest doing research. A recent study showed that in healthy individuals Metformin had no impact on all-cause mortality and there ar

First and foremost I would suggest doing research. A recent study showed that in healthy individuals Metformin had no impact on all-cause mortality and there are potential side effects. Of course, doing research is hard. Because it isn't really research in the sense of running a legitimate study, it's research in the sense of studying the work of others as an outsider. Personally, I like Dr Brad Stanfield. https://www.youtube.com/c/DrBradStanfield https://www.youtube.com/c/DrBradStanfield He's not afraid to reverse positions, he's articulate, he calls out when research is or is not compelling and explains why. Again, personally, I expect the number one thing you can do to improve your healthspan is probably focus on what you can stop putting in your body vs what things you can add. If you're 40+ though, might be worth looking at other options.

sometimeshuman 5y ago
Berberine is commonly promoted as a vitamin alternative to Metformin. Even if Berberine also has no impact on all-cause mortality (idk), I can anecdotally share that 500mg 30minutes before lunch considerably lessens my post lunch fatigue. As for human growth hormone, this Huberman Labs podcast advises against taking it but also offers many natural ways you can boost it[0]. [0]https://www.youtube.com/watch?v=x7qbJeRxWGw https://www.youtube.com/watch?v=x7qbJeRxWGw
inglor_cz 5y ago
In this concrete study (TRIIM and TRIIM-Extended), metformin isn't used for any putative anti-aging effects. It is used to counteract the effects of HGH on insulin levels. HGH increases insulin levels, which is known to be deleterious to the organism, and metformin serves to reduce them back.