10 ms·
The best meta-study review of Ivermectin I've seen was done by Scott Alexander [0]. He individually reviewed a few dozen studies. His take was that Ivermectin i
by ucha 5y ago
The best meta-study review of Ivermectin I've seen was done by Scott Alexander [0]. He individually reviewed a few dozen studies. His take was that Ivermectin is an effective dewormer that is useful as a prophylactic when people are widely exposed to worms. Because they don't catch worms, they're in better shape to fight Covid when infected. However Ivermectin has no effect in most developed countries where the general population isn't subject to worm infections.
[0] https://astralcodexten.substack.com/p/ivermectin-much-more-than-you-wanted https://astralcodexten.substack.com/p/ivermectin-much-more-t...
- felideon 5y agoHe also describes one of Cadegiani's other studies with some helpful color.
- disruptalot 5y agoI would also read ivmmeta's response [0] and his reply [1] . At first I walked away fairly confident at what I had read. Later when I came across the responses, things got more uncertain. The example which quickly comes to mind is that most if not all the prophylaxis studies were not reviewed in Scott's analysis. [0] https://ivmmeta.com/#sa https://ivmmeta.com/#sa [1] https://astralcodexten.substack.com/p/higlights-from-the-comments-on-ivermectin https://astralcodexten.substack.com/p/higlights-from-the-com...
- rsfern 5y agoThe Covid therapeutic and prophylactic literature has been chock full of crap studies, so you really have to be careful taking meta analysis at face value. Some interesting discussion on this, which includes the prophylactic literature: https://www.nature.com/articles/s41591-021-01535-y https://www.nature.com/articles/s41591-021-01535-y
- dionian 5y agoSame issue with relying on single studies, you might rely on a crap one.
- nikolay 5y agoExcept that ivermectin has been used as antiviral well before the pandemic though. I'm not sure why people assume that doctors tried just random drugs without any rationale behind it!
- giardini 5y agoI eagerly await the double-blind randomized studies that prove Scott Alexander to be correct!8-))