5 ms·

Ivermectin is also apparently a potent protease inhibitor. Inhibition of protease sabotages viral replication. Does that change the picture for you?

bayesian_horse 5y ago
Not at dosages a Human would survive.
maxerickson 5y ago
It's not potent against SARS-CoV-2 though. Here's a comparison with the Pfizer drug: https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967 https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlov...
Mvandenbergh 5y ago
At what IC50?
vintermann 5y ago
Even if it was, (I don't know why you believe that), protease inhibitors need to match the enzymes a virus uses. It would be very odd and surprising if a pharmaceutical with a completely different mechanism and purpose would just happen to inhibit coronavirus proteases.
martneumann 5y ago
Man, aren't people tired of reposting the same things? This was only shown in a petri dish at very high concentrations. You could say the same about a number of chemicals which we also would not survive in that concentration. I do not understand why people want Ivermectin to work so badly.
- notreallyserio 5y ago
  As far as I can tell it's either a desire for a certain political team to be right, people wanting to be contrarian above all else, and a belief that if an authority says something is likely false it's a conspiracy.
  - ComradePhil 5y ago
    Correct, but not for the reason you may think. As a non-American, I can tell you the only people around me who are really sure about this new unknown disease one way or other are those who follow the American news too much. They're really defensive about their positions as well well. It seems American media has nailed how to really brainwash the masses. It seems to involve a story where they really shame some people for being stupid (the people don't actually have to be stupid, just should be presentable as such with loaded questions, clever editing... what have you) and then while the people are experiencing second hand embarassment for the person, feed them what they need to think to not be ridiculed in mass media like this. This seems to work way too well and it seems they use it ALL THE TIME. Almost every "comedy news show" or opinion piece seems to be formatted like this.
    - cymian 5y ago
      Exactly.
- maupin 5y ago
  Sadly, I do.
- marcodiego 5y ago
  > I do not understand why people want Ivermectin to work so badly. In Brazil, ivermectin working means the president was right. That's why there is such a big effort in Brazil to make it work.
  - ComradePhil 5y ago
    And India.
- WaxedChewbacca 5y ago
- ConceptJunkie 5y ago
  > You could say the same about a number of chemicals which we also would not survive in that concentration. Yeah, look at AZT as an example.
rsfern 5y ago
You’re describing use as an antiviral, comparable to paxlovid. I don’t think that is the proposed mechanism for this prophylactic ivermectin treatment. If you have a reference you could share, that would be helpful. > Ivermectin does inhibit the same protease that PF-07321332 does, but, as is the case for viral replication, it requires a concentration that is not achievable by oral dosing. https://sciencebasedmedicine.org/pfizer-new-covid-19-protease-inhibitor-drug-is-not-just-repackaged-ivermectin/ https://sciencebasedmedicine.org/pfizer-new-covid-19-proteas...
m0llusk 5y ago
Protease inhibitors are amazingly powerful, but also very difficult to make work in practice. Many protease inhibitors have been developed and abandoned.

bayesian_horse 5y ago

Not at dosages a Human would survive.

maxerickson 5y ago

It's not potent against SARS-CoV-2 though. Here's a comparison with the Pfizer drug: https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967 https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlov...

Mvandenbergh 5y ago

At what IC50?

vintermann 5y ago

Even if it was, (I don't know why you believe that), protease inhibitors need to match the enzymes a virus uses. It would be very odd and surprising if a pharmaceutical with a completely different mechanism and purpose would just happen to inhibit coronavirus proteases.

martneumann 5y ago

Man, aren't people tired of reposting the same things? This was only shown in a petri dish at very high concentrations. You could say the same about a number of chemicals which we also would not survive in that concentration. I do not understand why people want Ivermectin to work so badly.

notreallyserio 5y ago
As far as I can tell it's either a desire for a certain political team to be right, people wanting to be contrarian above all else, and a belief that if an authority says something is likely false it's a conspiracy.
- ComradePhil 5y ago
  Correct, but not for the reason you may think. As a non-American, I can tell you the only people around me who are really sure about this new unknown disease one way or other are those who follow the American news too much. They're really defensive about their positions as well well. It seems American media has nailed how to really brainwash the masses. It seems to involve a story where they really shame some people for being stupid (the people don't actually have to be stupid, just should be presentable as such with loaded questions, clever editing... what have you) and then while the people are experiencing second hand embarassment for the person, feed them what they need to think to not be ridiculed in mass media like this. This seems to work way too well and it seems they use it ALL THE TIME. Almost every "comedy news show" or opinion piece seems to be formatted like this.
  - cymian 5y ago
    Exactly.
maupin 5y ago
Sadly, I do.
marcodiego 5y ago
> I do not understand why people want Ivermectin to work so badly. In Brazil, ivermectin working means the president was right. That's why there is such a big effort in Brazil to make it work.
- ComradePhil 5y ago
  And India.
WaxedChewbacca 5y ago
ConceptJunkie 5y ago
> You could say the same about a number of chemicals which we also would not survive in that concentration. Yeah, look at AZT as an example.

rsfern 5y ago

You’re describing use as an antiviral, comparable to paxlovid. I don’t think that is the proposed mechanism for this prophylactic ivermectin treatment. If you have a reference you could share, that would be helpful. > Ivermectin does inhibit the same protease that PF-07321332 does, but, as is the case for viral replication, it requires a concentration that is not achievable by oral dosing. https://sciencebasedmedicine.org/pfizer-new-covid-19-protease-inhibitor-drug-is-not-just-repackaged-ivermectin/ https://sciencebasedmedicine.org/pfizer-new-covid-19-proteas...

m0llusk 5y ago

Protease inhibitors are amazingly powerful, but also very difficult to make work in practice. Many protease inhibitors have been developed and abandoned.