3 ms·
If the drugs can't enter due to the BBB isn't the only chance to prime his immune system to handle it? Maybe another use case for specialized mRNA vaccines?
by carlmr 5y ago
If the drugs can't enter due to the BBB isn't the only chance to prime his immune system to handle it? Maybe another use case for specialized mRNA vaccines?
- eternityforest 5y agoWhy can't the put drugs directly on the other side of the barrier? Or is it not a physical thing with sides like that?
- deleted 5y ago[deleted]
- penjelly 5y agopretty sure you cant inject drugs directly into your brain
- meepmorp 5y agoThey can and do put drugs directly on the other side of the barrier. Intrathecal administration typically uses an infusion pump to put drugs directly into the cerebrospinal fluid. Pain meds are a common use case, as well as some chemotherapy drugs. It's a somewhat risky MOA, as the likely path of infection will proceed immediately to the life threatening stage, which means not many drugs are approved by this route.
- sjg007 5y agoDoctors can do intrathecal antifungal administration. I wonder if this guy has tried that.
- mateo1 5y agoThe blood brain barrier is the walls of the arteries. Perhaps you can "inject" something in the interstitial fluid but I imagine the volume would be tiny and fluid motion very slow.