4 ms·
Excellent! As a structural biologist, I found the coolest part of the entire approach to be the use of energetically favorable FoldIt model as a staring point f
by shiven 15y ago
Excellent! As a structural biologist, I found the coolest part of the entire approach to be the use of energetically favorable FoldIt model as a staring point for "molecular replacement".
I guess, this story highlights quite elegantly the "protein folding problem" to be a canonical "P vs NP" problem! Exciting times!!
- kayhi 15y agoI've had some success using the Zhang server (I-TASSER) to generate a model for MR. The benefit ended up being finding a domain, which we hadn't known based on our amino acid sequence. Exciting times indeed.
- shiven 15y agoThis seems to be in the same vein, kayhi : http://www.slideshare.net/ijstokes/wide-search-molecular-replacement-and-the-nebiogrid-portal-interface http://www.slideshare.net/ijstokes/wide-search-molecular-rep... Will be used for my next project!