Given that large businesses are taxed and impeded to hell and employees are taxed to the bone, is there any leg up for those running a single man sole proprieto

Given that large businesses are taxed and impeded to hell and employees are taxed to the bone, is there any leg up for those running a single man sole proprietorship running business informally? As a total outsider I feel like there's a special niche area left for 1 man run-his-own-business opportunities to make a living here by exploiting the structural problems that weaken the marketability of larger business.