I have done this with Twisted and have yet to see any problems. In your requirements.txt, add "Twisted". In your procfile, try something like: web: bin/py

I have done this with Twisted and have yet to see any problems. In your requirements.txt, add "Twisted". In your procfile, try something like: web: bin/python ./twistd -n web --port=$PORT --wsgi fully.qualified.app.name