If we assume that most studies that get into Nature Neuroscience are NIH R01s, which have a cap before you need to start fleshing out the budget in exacting det

If we assume that most studies that get into Nature Neuroscience are NIH R01s, which have a cap before you need to start fleshing out the budget in exacting detail of $125,000 in direct costs per year, and we assume a 50% overhead rate... We get $937,500. That's not far off, and center grants, large cooperative agreements, etc. probably give the distribution a decently long tail.