4 ms·

Time to mainline it directly into your eyeballs

• actually_a_dog 5y ago
  In all seriousness, taking it sublingually might actually be extremely effective. Sublingual delivery tends to be more effective with lipophillic substances than hydrophilic substances. Caffeine is a bit weird in that it is hydrophilic, but, it is sufficiently lipophyllic to cross cell membranes and penetrate the blood/brain barrier, which is what makes me suspect it would work out well.
  • kortex 5y ago
    Sublingual caffeine is definitely a thing. There is caffeinated gum you can get on Amazon. You can feel it kick in almost immediately.
    • actually_a_dog 5y ago
      Huh. Technically, that would probably be considered buccal (via the cheek) delivery, but, close enough, right? I had no idea caffeinated gum kicked in significantly faster than pills or drinks. https://en.wikipedia.org/wiki/Buccal_administration https://en.wikipedia.org/wiki/Buccal_administration
      • kortex 5y ago
        Yep, good catch. "buccal administration" is a bit more obscure so I often just refer to sublingual unless I know the audience. Mucosal absorption is definitely way faster than pills (unless you chew them) or drink. One time a friend and I tried making caffeine patches with DMSO as a transport, and put it on our arms with a cotton ball and tape...NOT PLEASANT. Extreme pruritus and erythema at the administration site. Hoo boy were we alert though. Nowadays the gum is perhaps a bit too fast even, it's easy to overdue and I get palpitations. Follow me for more horrible ideas and biohacks. /s. I don't actually have a channel for my misadventures and shenanigans...maybe I should?