9 ms·

I was debating whether or not to post some of those self-experiments. I'm aware of a couple more forums where people tried ISRIB and still claim to have lastin

I was debating whether or not to post some of those self-experiments. I'm aware of a couple more forums where people tried ISRIB and still claim to have lasting problems from it. One group was led by professional chemists who seemed like they knew what they were doing when it comes to testing and validating the product was pure. It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea.

meowface 5y ago
Reminds me a bit of cerebrolysin self-experiments I've read. It can either permanently make you smarter or permanently give you brain damage. Or both, perhaps. (For anyone unaware, it's a bunch of neuropeptides harvested from pig brains that you typically either inject or - fittingly, due to the source - snort directly into your brain through your nose.)
- texasbigdata 5y ago
  "Smarter" do you mean neuroregenesis? As I understood it's used post stroke to try to reverse some of the damage.
treeman79 5y ago
Developed a weird dementia at 39. Doctors Spent 2 years trying every prescription drug they could think of. Almost everything made matters worse. In some cases drastically. Complete nightmare. Those are with approved ones. Scary to try experiential. Eventually learned it was a blood disorder and a simple blood thinner was the answer.
- nefitty 5y ago
  Wow. It sounds like you're better and hope you're better! That's an incredible story. Good on you for not giving up. You just lit a fire under my butt.
- cma 5y ago
  Which blood disorder?
  - treeman79 5y ago
    Factor 5 Leiden. I clot easily. So mini strokes. Turns out tiny clots don’t show up on MRIs.
    - texasbigdata 5y ago
      Very interested in this. So your c-reactive protein, d-dimer (sp?), etc etc showed negative? How did you find the clots? When you say "tiny", in medical terms do you mean mili or micro meters (I think that's right). You might like the #1 book on Amazon under cardiology currently. Its thesis is cholesterol has nothing to do with heart diseases, its all in the clots. Good detail of the clotting process and relatively understandable.
      - treeman79 5y ago
        Had a Pulmary embolism. Was gasping for air and coughing up flecks of blood. At the Er the Blood work was perfect. D-dimer, everything. Genetic testing came back positive later on. So they put on blood thinners. A few days later my dementia was gone. Was solving complex programming problems with ease once more. Every time I try and go off them all the symptoms come back. So it was this that micro-clots was determined. Also when drawing blood nurses kept complaining that my blood clots to fast.
- dennisgorelik 5y ago
  How did you learn it was a blood disorder?
tomComb 5y ago
> It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea. I think it depends what the alternative is. If you have something like Alzheimer’s and no other alternatives, maybe self-experimentation is not such a bad idea.

meowface 5y ago

Reminds me a bit of cerebrolysin self-experiments I've read. It can either permanently make you smarter or permanently give you brain damage. Or both, perhaps. (For anyone unaware, it's a bunch of neuropeptides harvested from pig brains that you typically either inject or - fittingly, due to the source - snort directly into your brain through your nose.)

texasbigdata 5y ago
"Smarter" do you mean neuroregenesis? As I understood it's used post stroke to try to reverse some of the damage.

treeman79 5y ago

Developed a weird dementia at 39. Doctors Spent 2 years trying every prescription drug they could think of. Almost everything made matters worse. In some cases drastically. Complete nightmare. Those are with approved ones. Scary to try experiential. Eventually learned it was a blood disorder and a simple blood thinner was the answer.

nefitty 5y ago
Wow. It sounds like you're better and hope you're better! That's an incredible story. Good on you for not giving up. You just lit a fire under my butt.
cma 5y ago
Which blood disorder?
- treeman79 5y ago
  Factor 5 Leiden. I clot easily. So mini strokes. Turns out tiny clots don’t show up on MRIs.
  - texasbigdata 5y ago
    Very interested in this. So your c-reactive protein, d-dimer (sp?), etc etc showed negative? How did you find the clots? When you say "tiny", in medical terms do you mean mili or micro meters (I think that's right). You might like the #1 book on Amazon under cardiology currently. Its thesis is cholesterol has nothing to do with heart diseases, its all in the clots. Good detail of the clotting process and relatively understandable.
    - treeman79 5y ago
      Had a Pulmary embolism. Was gasping for air and coughing up flecks of blood. At the Er the Blood work was perfect. D-dimer, everything. Genetic testing came back positive later on. So they put on blood thinners. A few days later my dementia was gone. Was solving complex programming problems with ease once more. Every time I try and go off them all the symptoms come back. So it was this that micro-clots was determined. Also when drawing blood nurses kept complaining that my blood clots to fast.
dennisgorelik 5y ago
How did you learn it was a blood disorder?

tomComb 5y ago

> It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea. I think it depends what the alternative is. If you have something like Alzheimer’s and no other alternatives, maybe self-experimentation is not such a bad idea.