3 ms·
Ivermectin is not a protease inhibitor. From wikipedia: > Ivermectin and its related drugs act by interfering with the nerve and muscle functions of helminths
by 323 5y ago
Ivermectin is not a protease inhibitor. From wikipedia:
> Ivermectin and its related drugs act by interfering with the nerve and muscle functions of helminths and insects. The drug binds to glutamate-gated chloride channels common to invertebrate nerve and muscle cells.
Cited from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853155/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853155/
- greggeter 5y agoProtease binding is in fact a thing that Ivermctn does: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
- greggeter 5y agoFrom the article I cited: "Taken together, our data on the interaction between ivermectin and viral proteins indicated that ivermectin majorly acts by interfering with the viral entry through inhibiting the function of spike protein and protease. "
- wrp 5y agoThere does seem to be some protease inhibition involved. An in silico data analysis conducted by Choudhury et al. demonstrated that ivermectin efficiently utilizes viral spike protein, main protease, replicase, and human TMPRSS2 receptors as the most possible targets for executing its "antiviral efficiency" by disrupting binding.[1] [1] https://www.nature.com/articles/s41429-021-00491-6 https://www.nature.com/articles/s41429-021-00491-6