4 ms·

Really interesting to take in all these details. Protease inhibitors have raised great hopes for many years, but actually making them work as expected has run

Really interesting to take in all these details. Protease inhibitors have raised great hopes for many years, but actually making them work as expected has run into all kinds of problems and in general has been a colossal failure that used up enormous amounts of money and effort. To my knowledge this is the first strongly effective protease inhibitor be used in humans, but it would be nice to hear about any other successes.

323 5y ago
Not an expert, but this 1996 paper talks about a highly effective HIV protease inhibitor: https://pubmed.ncbi.nlm.nih.gov/11363781/ https://pubmed.ncbi.nlm.nih.gov/11363781/
shrubble 5y ago
Pepcid AC, an over the counter drug, contains famotidine, which is also a 3CLpro protease inhibitor (but testing didn't seem to indicate it would work against covid). It's been used in humans for many many years...