It can be used with MVC, but the problem is MVC is still C# centric - as in the scaffolding bits that it generates are C# (or VB). There's also the question of

It can be used with MVC, but the problem is MVC is still C# centric - as in the scaffolding bits that it generates are C# (or VB). There's also the question of Razor supporting F#, which is not yet there. I remember somebody spiking some code for that, not sure if it's usable. You can still write all your controllers in F#; but if your front-end is C#(razor), and if your data access is in L2S or EF, then F# feels like added baggage. Still could be useful in some occasions.