If dermatologists worked like psychiatrists they wouldn't be able to tell acne and chickenpox apart (and they'd treat both with face powder). One of the worse

If dermatologists worked like psychiatrists they wouldn't be able to tell acne and chickenpox apart (and they'd treat both with face powder). One of the worse example is schizophrenia, which is attributed if you have at least two symptoms out of a list of five (meaning that people with totally distinct symptoms end up with the same diagnosis). There were genome-wide association studies in the 2010's that identified 7 or 8 distinct transcription factor networks with polymorphisms associated with a risk of schizophrenia. Every network is associated with the same symptoms. In other words schizophrenia is likely at least 7 distinct diseases that are so orphaned they don't have a name. Another example is eating disorders, where both bulimia and anorexia are probably underpinned by the same pathology that involves an auto-immune response following a cross-reaction to a bacterial protein that mimics a satiety hormone.