5 ms·

Note that this data is pre-omicron.

ceejayoz 5y ago
We've got some Omicron data that shows similar results. Massive gap between unvaccinated and vaccinated case/death/hospitalization rates. https://www.nytimes.com/2022/01/11/briefing/omicron-deaths-vaccinated-vs-unvaccinated.html https://www.nytimes.com/2022/01/11/briefing/omicron-deaths-v... has charts.
- Vthrowaway153 5y ago
  From https://www.nytimes.com/2022/01/11/health/california-omicron-hospitalizations.html https://www.nytimes.com/2022/01/11/health/california-omicron...: > Compared with Delta, Omicron infections were half as likely to send people to the hospital. Out of more than 52,000 Omicron patients identified from electronic medical records of Kaiser Permanente of Southern California, a large health system, the researchers found that not a single patient went on a ventilator during that time. > Compared with Delta, Omicron cut the risk of hospitalization in half, the study found, and the people who came to the hospital with Omicron stayed for a shorter period. The variant cut hospital stays by more than three days, a reduction of 70 percent compared with Delta. > Fourteen of the Delta-infected patients died, while only one Omicron patient did. > “Vaccines are quite helpful,” Dr. Lewnard said. He and his colleagues found that Californians who were vaccinated were 64 to 73 percent less likely to be hospitalized than unvaccinated people. > Even among unvaccinated people, however, Omicron was less likely to lead to hospitalizations than Delta. The absolute numbers are hard to ignore. Tens of thousands of patients in the studies referenced. None went on a ventilator. One died. But when it comes to boosters, we're not even comparing the vaccinated to the unvaccinated. We're comparing the previously "fully vaccinated" to the boosted and asking what real benefit there is to get boosted for people who are not at high risk (i.e. above >70, with multiple comorbidities) and who almost certainly retain meaningful protection from cell-mediated immunity produced as a result of the initial 2-dose series in the face of a variant that a) causes less severe illness generally and b) for which the antibodies our current vaccines produce are far less effective at neutralizing.
2muchcoffeeman 5y ago
I think it’s hard to get good data anymore since so many people are vaccinated. I’ve heard one news outlet report that some scientists were trying to analyse the unvaccinated data only and initial findings were showing Omicron may be just as bad as Alpha. But small sample size etc etc so we really don’t know.
- ceejayoz 5y ago
  There are tens of millions of unvaccinated in the US alone. Plenty of data to be had.
  - kcplate 5y ago
    But the meaningful data which is increased illness severity and higher chances of death are concentrated in 65+ age brackets which are 95%/88%/62% (1/2/3 shot vaccinated) in the US. As you fall in ages it’s less % vaccinated, but also the chance of a severe case among the unvaccinated drops too…dramatically. So yes, tens of millions unvaccinated, but also tens of millions that can’t really be measured as effectively either.
    - ceejayoz 5y ago
      If we can have statistically valid results from 40k clinical trial participants, 5% of the 65+ population being unvaccinated is plenty of data to base conclusions on.
      - heavyset_go 5y ago
        One issue I'd could imagine is that it might be difficult to slice a representative sample out of those 5% of people, whereas a clinical trial is set up from the get-go to enroll individuals that would make up a representative sample of the intended recipients of the drug/procedure/device that's being studied.
        kcplate 5y ago

We've got some Omicron data that shows similar results. Massive gap between unvaccinated and vaccinated case/death/hospitalization rates. https://www.nytimes.com/2022/01/11/briefing/omicron-deaths-vaccinated-vs-unvaccinated.html https://www.nytimes.com/2022/01/11/briefing/omicron-deaths-v... has charts.

Vthrowaway153 5y ago
From https://www.nytimes.com/2022/01/11/health/california-omicron-hospitalizations.html https://www.nytimes.com/2022/01/11/health/california-omicron...: > Compared with Delta, Omicron infections were half as likely to send people to the hospital. Out of more than 52,000 Omicron patients identified from electronic medical records of Kaiser Permanente of Southern California, a large health system, the researchers found that not a single patient went on a ventilator during that time. > Compared with Delta, Omicron cut the risk of hospitalization in half, the study found, and the people who came to the hospital with Omicron stayed for a shorter period. The variant cut hospital stays by more than three days, a reduction of 70 percent compared with Delta. > Fourteen of the Delta-infected patients died, while only one Omicron patient did. > “Vaccines are quite helpful,” Dr. Lewnard said. He and his colleagues found that Californians who were vaccinated were 64 to 73 percent less likely to be hospitalized than unvaccinated people. > Even among unvaccinated people, however, Omicron was less likely to lead to hospitalizations than Delta. The absolute numbers are hard to ignore. Tens of thousands of patients in the studies referenced. None went on a ventilator. One died. But when it comes to boosters, we're not even comparing the vaccinated to the unvaccinated. We're comparing the previously "fully vaccinated" to the boosted and asking what real benefit there is to get boosted for people who are not at high risk (i.e. above >70, with multiple comorbidities) and who almost certainly retain meaningful protection from cell-mediated immunity produced as a result of the initial 2-dose series in the face of a variant that a) causes less severe illness generally and b) for which the antibodies our current vaccines produce are far less effective at neutralizing.

2muchcoffeeman 5y ago

I think it’s hard to get good data anymore since so many people are vaccinated. I’ve heard one news outlet report that some scientists were trying to analyse the unvaccinated data only and initial findings were showing Omicron may be just as bad as Alpha. But small sample size etc etc so we really don’t know.

ceejayoz 5y ago
There are tens of millions of unvaccinated in the US alone. Plenty of data to be had.
- kcplate 5y ago
  But the meaningful data which is increased illness severity and higher chances of death are concentrated in 65+ age brackets which are 95%/88%/62% (1/2/3 shot vaccinated) in the US. As you fall in ages it’s less % vaccinated, but also the chance of a severe case among the unvaccinated drops too…dramatically. So yes, tens of millions unvaccinated, but also tens of millions that can’t really be measured as effectively either.
  - ceejayoz 5y ago
    If we can have statistically valid results from 40k clinical trial participants, 5% of the 65+ population being unvaccinated is plenty of data to base conclusions on.
    - heavyset_go 5y ago
      One issue I'd could imagine is that it might be difficult to slice a representative sample out of those 5% of people, whereas a clinical trial is set up from the get-go to enroll individuals that would make up a representative sample of the intended recipients of the drug/procedure/device that's being studied.
      - kcplate 5y ago