That's interesting, but I don't see how it's related to OP's point. (Which was ostensibly about legitimate donations to legitimate non-profits, but was apparent

That's interesting, but I don't see how it's related to OP's point. (Which was ostensibly about legitimate donations to legitimate non-profits, but was apparently actually about gambling, porn, and politics...) Using fraud detection technology and/or swallowing the chargeback fees would probably be cheaper than the overhead of using a crpytocurrency+exchange. Setting a minimum donation so that you're not a good target for card testing probably has a lower barrier to entry than requiring use of a crpytocurrency.