There are interactions that the wiring diagram doesn't account for. For example, some neurons release "neuromodulators" that diffuse beyond their immediate syn

There are interactions that the wiring diagram doesn't account for. For example, some neurons release "neuromodulators" that diffuse beyond their immediate synaptic partners. Electric fields produced by a fiber bundle can affect activity in neighboring neurons. Inside the cell, there are all kinds of processes on short (millisecond) and long (day) timescales that alter how the same neuron responds to identical stimuli.