Of course everything can be made to work but in my experience and from what I've heard from others there are some cultural differences, language barriers and ti

Of course everything can be made to work but in my experience and from what I've heard from others there are some cultural differences, language barriers and time zone problems that makes this is bit less efficient and sometimes outright hard. For a small or medium company it may also be a bit more work to handle foreign employment laws and tax laws.