https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ One of the main reasons Moderna pivoted to

https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ One of the main reasons Moderna pivoted to vaccine development was because the liquid nanoparticles used to deliver the mRNA are toxic, and the necessary dosages for a therapeutic dose were dangerous. Fortunately, vaccines require smaller doses, and were originally thought of as one-shot deals, so accumulation wasn't a concern. > Yet Moderna could not make its therapy work, former employees and collaborators said. The safe dose was too weak, and repeat injections of a dose strong enough to be effective had troubling effects on the liver in animal studies. At any rate, we have very poor understanding of the body and biology in general. I don't care what models say about long-term safety - this is an exactly backwards way to look at it, and why technological development has had devastating impacts on the ecosystem and on human health. We don't know what we don't know. And we very often don't worry too much about what we don't know when a "solution" presents itself, especially if someone can profit off that solution, whether it's trans-fats, DDT, or Vioxx. I care about what long-term safety records say about long-term safety. For similar reasons, I decline to take nearly all medication unless my life is in imminent danger or the expected benefit is very large and the known risks have been tracked for decades. (So - pretty much just antibiotics when I have a severe infection that is not getting better.)