3 ms·
You're right, he is wrong. But you're also wrong. Intramuscular vaccination only will never prevent sars-cov-2 infection or spread. Just like it doesn't with in
by superkuh 5y ago
You're right, he is wrong. But you're also wrong. Intramuscular vaccination only will never prevent sars-cov-2 infection or spread. Just like it doesn't with influenza a. It isn't just about people not getting vaccinated. The problem is that we're not following up the intramuscular vaccination with an intranasal vaccination booster.
Intramuscular vaccination for upper respiratory aerosol viral diseases does protect your internal body from serious disease. It does that partially with antibody neutralization (via B cells) and with variants, mostly with cross reactive T cells which kill any of your infected cells.
But those B and T cells are in the body serum immune compartment. The serum igG antibodies generated by intramuscular vaccination do seep into your lower lungs a bit and provide protection. But they barely get into the upper respiratory surface tissues (mucosa) and for less than a couple months even at those low levels. And none of the T cells (or B cells making antibodies) become resident in the upper respiratory tissues where infection happens.
This means the upper respiratory mucosa immune compartment can and is still infected and spreads sars-cov-2. Even if sars-cov-2 has 70x less chance of killing you now. It means that tests for infection in the nose/throat/etc will return positive. And it means the intramuscularly vaccinated can and do spread sars-cov-2 and have to wear N95/ffp2 masks like everyone.
The intramuscular vaccination is only the FIRST STEP. The second is intranasal vaccination so that there are tissue resident B and T cells in the upper respiratory mucosa to prevent infection and spread.
It's incredibly frustrating to me (and probably others in the know) that no institutions or governments have acted on this well known historical fact (been known since the 1960s). If we go based off the time it took governments to realize everyone needs to be wearing a proper fit mask with no gaps then they should realize the value of intranasal vaccines about 2 years from now.
- toss1 5y agoYES. I fully agree that the measures are insufficient AND that addition of intranasal vaccines to those measures would be even better. The greater measures we should be taking was out of scope; I was merely trying to show that the other complaint saying 'why bother with measures when they don't work' is entirely in the wrong direction -- the fact that this vastly more infectious variant is producing wave similar in scope to the original and Delta waves shows that the measures ARE working -- without them, this more infectious strain would be far worse.