I recommend using Twitter's search if you want to find tweets on a particular topic. If someone posts several worthwhile tweets, you can follow them. Over time,

I recommend using Twitter's search if you want to find tweets on a particular topic. If someone posts several worthwhile tweets, you can follow them. Over time, you'll start getting retweets of good content. You can follow those people. Use Tweetdeck and create lists by topic. The most important thing is to take your time. There's no way I'd let Twitter tell me which tweets I should see. You're going to end up with people that promote themselves and their friends, and that promotion gets annoying in a hurry - if I wanted that I'd watch QVC. I mostly try to avoid accounts with more than 100K followers. A lot of them post information of questionable accuracy because that's how you generate interest in your account. Moreover, they aren't likely to interact unless you're in their inner circle, which makes for a boring experience.