4 ms·

That’s not correct, furin cleavage sites naturally occur in coronaviruses: https://www.sciencedirect.com/science/article/pii/S1873506120304165 https://www.scien

• moralestapia 5y ago
  >To clarify this sequence has not been identified in any other virus in the wild. >this sequence >this >sequence
• Jimmc414 5y ago
  You are correct. I should have stated furin cleavage sites have not been observed in another beta coronavirus. (Cold, MERS, SARS) I corrected my statement. Thank you for pointing that out.
  • etaoins 5y ago
    That’s still incorrect. MERS is a Betacoronavirus and has a furin cleavage site: https://www.pnas.org/content/pnas/111/42/15214.full.pdf https://www.pnas.org/content/pnas/111/42/15214.full.pdf Furin clevage sites haven’t been found elsewhere in SARS-Cov-2’s Sarbecovirus subgenus.
• finite_jest 5y ago
  Not with the same PRRAR sequence of amino acids, right?
  • etaoins 5y ago
    Right, the furin cleavage site seems to have occurred independently in SARS-CoV-2 or one of its undiscovered close relatives.