3 ms·
To clarify this sequence has not been identified in any other virus in the wild. Additionally it codes for the section pertaining to the furin cleavage site wh
by Jimmc414 5y ago
To clarify this sequence has not been identified in any other virus in the wild. Additionally it codes for the section pertaining to the furin cleavage site which does not exist in any other observed beta coronavirus.
- etaoins 5y agoThat’s not correct, furin cleavage sites naturally occur in coronaviruses: https://www.sciencedirect.com/science/article/pii/S1873506120304165 https://www.sciencedirect.com/science/article/pii/S187350612...
- moralestapia 5y ago>To clarify this sequence has not been identified in any other virus in the wild. >this sequence >this >sequence
- Jimmc414 5y agoYou are correct. I should have stated furin cleavage sites have not been observed in another beta coronavirus. (Cold, MERS, SARS) I corrected my statement. Thank you for pointing that out.
- etaoins 5y agoThat’s still incorrect. MERS is a Betacoronavirus and has a furin cleavage site: https://www.pnas.org/content/pnas/111/42/15214.full.pdf https://www.pnas.org/content/pnas/111/42/15214.full.pdf Furin clevage sites haven’t been found elsewhere in SARS-Cov-2’s Sarbecovirus subgenus.
- finite_jest 5y agoNot with the same PRRAR sequence of amino acids, right?
- etaoins 5y agoRight, the furin cleavage site seems to have occurred independently in SARS-CoV-2 or one of its undiscovered close relatives.