I'm afraid this is out of my scope of understanding. Once the immune system determines something is non-self, the immune system can often self-propagate the re

I'm afraid this is out of my scope of understanding. Once the immune system determines something is non-self, the immune system can often self-propagate the response. It eventually enters a tolerance phase where it aims to just 'control' the threat. There are some known modulators of the immune system, but the medical forms can be especially blunt tools (i.e. steroids). Locally directed treatment is better, and maybe in the future we'll have specially crafted cells that can inhibit a specific response for particular antigens. There is a long and slightly-controversial link between stress (and lots of other environmental factors) affecting the immune system. I'm not familiar with the literature.