4 ms·

If MS is a faulty immune response from EBV, wouldn't a vaccine theoretically and potentially trigger this same faulty immune response? There are obviously othe

If MS is a faulty immune response from EBV, wouldn't a vaccine theoretically and potentially trigger this same faulty immune response? There are obviously other causative factors influencing MS. One is EBV, the other is likely a specific type of immune system.

croes 5y ago
EBV stays in the human body, a vaccine wouldn't.
- deltaonefour 5y ago
  The immune system upon reacting to EBV or a vaccine should theoretically eliminate EBV on contact so it won't stay in your body? Are you implying that that a vaccine cannot eliminate EBV? Additionally, a faulty immune response also means your immune system can't differentiate between EBV and your nerve cells. So theoretically speaking even if there's no EBV in your body having MS means that your body thinks EBV is in your body even if it's not. A vaccine in my mind could still induce this reaction.
  - croes 5y ago
    I meant that it's unlikely that a EBV vaccine triggers the same response as EBV because EBV stays and the vaccine wouldn't. Same with the Corona vaccines unlike this implies https://news.ycombinator.com/item?id=29942670 https://news.ycombinator.com/item?id=29942670
- Metacelsus 5y ago
  Some vaccines (like VZV vaccine) persist in the body.
  - panabee 5y ago
    are you on twitter? your blog is highly educational. i'm interested in learning more about EBV and other viruses. for instance, given that VZV is common but not every infection causes shingles, how does VZV pass koch's postulates to establish causality? similar question applies to SARS-CoV-2 and CRS.
vintermann 5y ago
Climate is also a known factor. MS is more prevalent in temperate climates. A study from some years back suggested that if you move before the age of 15 or so, you get the risk of your new climate instead.
epgui 5y ago
Short answer is no. Long answer is that the question is premature (we need to answer more mechanistic questions first, and then we need to have an actual potential vaccine strategy to talk about) and there is currently no particular reason to suspect this.
adnmcq999 5y ago
That’s why I won’t MRNA

croes 5y ago

EBV stays in the human body, a vaccine wouldn't.

deltaonefour 5y ago
The immune system upon reacting to EBV or a vaccine should theoretically eliminate EBV on contact so it won't stay in your body? Are you implying that that a vaccine cannot eliminate EBV? Additionally, a faulty immune response also means your immune system can't differentiate between EBV and your nerve cells. So theoretically speaking even if there's no EBV in your body having MS means that your body thinks EBV is in your body even if it's not. A vaccine in my mind could still induce this reaction.
- croes 5y ago
  I meant that it's unlikely that a EBV vaccine triggers the same response as EBV because EBV stays and the vaccine wouldn't. Same with the Corona vaccines unlike this implies https://news.ycombinator.com/item?id=29942670 https://news.ycombinator.com/item?id=29942670
Metacelsus 5y ago
Some vaccines (like VZV vaccine) persist in the body.
- panabee 5y ago
  are you on twitter? your blog is highly educational. i'm interested in learning more about EBV and other viruses. for instance, given that VZV is common but not every infection causes shingles, how does VZV pass koch's postulates to establish causality? similar question applies to SARS-CoV-2 and CRS.

vintermann 5y ago

Climate is also a known factor. MS is more prevalent in temperate climates. A study from some years back suggested that if you move before the age of 15 or so, you get the risk of your new climate instead.

epgui 5y ago

Short answer is no. Long answer is that the question is premature (we need to answer more mechanistic questions first, and then we need to have an actual potential vaccine strategy to talk about) and there is currently no particular reason to suspect this.

adnmcq999 5y ago

That’s why I won’t MRNA