It's unlikely for cannabinoids other than THC to bind to the CB1 receptor strong enough to cause the psychoactive effect. Only THC binds very well to the CB1 r

It's unlikely for cannabinoids other than THC to bind to the CB1 receptor strong enough to cause the psychoactive effect. Only THC binds very well to the CB1 receptor. THCA does not bind well to either receptor. Cannabinoids that bind to CB2 receptors in the immune and gastrointestinal systems affect inflammatory and immune responses.