The Bangladesh study failed to produce a significant result when simpler nonparametric statistics were used to analyze the data. There were also significant dis

The Bangladesh study failed to produce a significant result when simpler nonparametric statistics were used to analyze the data. There were also significant discrepancies in the follow up rate between the control and treatment groups. And even if you ignore those issues, the absolute effect size (20 cases) was tiny. The effect size was expressed in terms of the relative rate of symptomatic seropositives, i.e., normalized by population denominators, which makes it appear larger and is sensitive to the follow up rate discrepancies (see above). Ben Recht at UC Berkeley has several good blog posts on this issue: https://www.argmin.net/2021/12/01/unblinding/ https://www.argmin.net/2021/12/01/unblinding/