3 ms·
The article states they changed a sugar that triggered rejection.
by Finnucane 5y ago
The article states they changed a sugar that triggered rejection.
- pazimzadeh 5y agoExactly: "More than 95% of human anti-pig antibodies are directed against 3 pig carbohydrates: Gal 1 to 3αGal (≈80%–90%), Neu5Gc (≈5%–15%), and β4Gal (1%–5%)" "To reduce anti-pig antibody binding to the xenograft, the 3 principal carbohydrate antigen targets have each been successfully removed from pigs by gene knockout (KO) (Figure 3)" Progress Toward Cardiac Xenotransplantation https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7990044/ https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7990044/