4 ms·
>Writing in Cell, Koren et al.3 demonstrate that inflammation in the abdominal cavity results in the stimulation of certain neurons in a brain area called the i
by eli_gottlieb 5y ago
>Writing in Cell, Koren et al.3 demonstrate that inflammation in the abdominal cavity results in the stimulation of certain neurons in a brain area called the insular cortex, or the insula. Artificial reactivation of these ‘immune-imprinted’ neurons is sufficient to generate organ-specific recall of inflammatory responses that resemble the initial inflammatory episode.
Ok, so there are gut/vagal interoceptors for inflammation. Their ascending fibers land in the insula, which is, of course, the primary interoceptive cortex. What's new here?
- ramraj07 5y agoWhat’s new is that the neurons can trigger back the same inflammation that got imprinted on them.
- 52-6F-62 5y agoI don't have access to the article, and I'm probably not versed enough to understand it fully anyway. So, if I may ask you, or the larger thread— this is implying the the inflammation will repeat if the neurons are activated [in such a way]? Could/would this impact one-time sufferers of SIRS and/or acute pancreatitis (being an inflammatory disease)? Would it match the original severity?
- eli_gottlieb 5y agoThey don't seem to have disentangled whether the same sensation of inflammation is triggered, or whether the actual inflammation is triggered by some visceromotor mechanism.